Sanval (ZOLPIDEM 10 mg) 20 Film Coated Tablets in Box by Sandoz

Indications of Sanval®
Sleep disturbances: difficulty falling asleep, early and nocturnal awakenings. Active substance:
zolpidem tartrate – By SANDOZ 
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Pharmacodynamics
Zolpidem is a hypnotic that belongs to the group of imidazopyridines. Differing in structure from benzodiazepines, zolpidem has a sedative effect, while the anxiolytic, anticonvulsant and central muscle relaxant effect is expressed slightly.

According to the classification, the allosteric sites of the GABA complex that benzodiazepines bind to are called omega-modulating sites or receptors. To date, three subtypes have been identified: 1, 2 and 3. Unlike benzodiazepines, which non-selectively bind and activate all three subtypes of omega receptors, zolpidem binds selectively to the omega1 receptor, therefore the sedative effect of the drug is observed at lower doses than doses necessary for the development of muscle relaxant, anticonvulsant and anxiolytic effect.

Omega1 receptors are mainly located in the fourth layer of the sensory cortex of the cerebral hemispheres, in the cerebellum, pons, and lower tubercles of the quadrocholium.

Zolpidem showed low affinity for omega2 receptors (lumbar spine, hippocampus) and omega3 receptors (certain peripheral areas). Modern experience shows that the pharmacological action of zolpidem is different from that of benzodiazepines.

Interaction with omega receptors leads to the discovery of neuronal ionophore channels for chlorine ions.

The effect comes quickly. It shortens the time of falling asleep, reduces the number of nighttime awakenings, increases the total duration of sleep and improves its quality. Extends stage II of sleep and stage of deep sleep (III and IV).
Pharmacokinetics
Zolpidem is rapidly absorbed from the gastrointestinal tract. After receiving a dose of 5 and 10 mg Cmax in plasma is 59 and 121 ng / ml, respectively, Tmax – from 0.5 to 3 hours (average Tmax – 1.6 hours).

Patients claim that this is a fairly high cost for a hypnotic. However, experts say that the price of this drug is justified, as it is good for insomnia and poor sleep. Most users fully agree with the latest statement. They respond well to the drug, but only if taken strictly according to the doctor’s prescription or instruction.

In their reports, patients say the drug in question allows them to fall asleep normally and quickly and also get a good night’s sleep after stress.