By HF – Hemofarm /STADA GRUP/
Lorazepam is a benzodiazepine with anxiolytic, sedative and hypnotic properties.
Lorazepam is almost completely absorbed from the gastrointestinal tract and peak serum levels are reached in 2 hours. It is metabolised by a simple one-step process to a pharmacologically inert glucuronide. There are no major active metabolites. The elimination half-life is about 12 hours and there is minimal risk of excessive accumulation.
NOT FOR USE
• Long term (i.e. longer than 4 weeks)
• For mild/moderate anxiety
• For insomnia or anxiety in children
Route of administration: oral
Treatment to be given:
• Under close medical supervision
• At the lowest effective dose
• For the shortest possible duration (not exceeding 4 weeks)
Doses should be individualised
Extension of use should not take place without further clinical evaluation
Chronic use not recommended (little is known of the long term safety and efficacy; potential for dependence–see section 4.4
When treatment is started the patient should be informed that
• treatment will be of limited duration
• the dosage will be progressively decreased
• there is a possibility of rebound phenomena
Anxiety: 1-4mg daily in divided doses.
Insomnia: 1-2mg before retiring
Premedication before operative dentistry or general surgery:
2-3mg the night before operation 2-4mg one to two hours before the procedure
The elderly may respond to lower doses (half normal adult dose or less)
Children (aged 5-13 years):
Premedication: 0.5-2.5mg at 0.05mg/kg to the nearest 0.5mg according to weight, not less than one hour before operation.
Patients with Renal or Hepatic impairment:
Lower doses may be sufficient in these patients (See section 4.4). Use in patients with severe hepatic insufficiency is contraindicated. (See section 4.6).