Helex /Xanax/ 1 mg (Alprazolam) 30 tablets in Box from KRKA


Therapeutic indications
• Anxiety disorders, with or without symptoms of depression. Symptoms of anxiety disorders manifest with anxiety, tension, fear, shyness, anxiety, poor concentration, irritability, insomnia and / or vegetative hyperactivity that can cause different physical disorders.

Depressive symptoms that may occur in patients with anxiety are manifested, e.g. depressed or dysphoric mood, loss of interest or satisfaction, decreased energy and psychomotor tension.
• Anxiety disorders and mixed disorders with anxiety-depression accompanying organic diseases and the chronic phase of alcohol withdrawal.
• Panic disorders.
4.2. Dosage and method of administration
The dosage should be individualized according to the severity of the symptoms and the individual response. The table shows a dosing scheme frame that meets the needs of most patients. For patients who require higher doses, the dosage should be increased cautiously to avoid side effects. First, the evening dose is then increased, then the daily dose.

Indication Initial treatment Maintenance treatment
Anxiety or anxiety with depressive symptoms Adults: 0.25 to 0.5 3 times a day Elderly: 0.25 nM 2 to 3 times daily Adults: 0.5 to 4 mg per day in 2 or 3 doses Elderly: 0.5 to 0.75% daily in 2 or 3 doses
Panic disorders 0.5 to 1 3 times a day (not to increase by more than 1 ea for 3 to 4 days) 4 to 10 mg / day in several doses

If undesirable effects are observed at baseline, the dose should be reduced.
Discontinuation of alprazolam therapy should be gradual because abrupt discontinuation may lead to withdrawal symptoms. These symptoms may be mild dysphoric reactions, insomnia, but also severe symptoms such as muscle and abdominal cramps, vomiting, sweating, tremor and convulsions. Gradual interruption should be prolonged, eg. if the patient is taking 0.5 mg in the morning, 0.5 mg at lunch and 1 mg in the evening, it is recommended that the daily dose be reduced by no more than 0.25 mg over three days.

Some physicians recommend that the daily dose be reduced by 0.5 mg over three days, regardless of its size. When typical withdrawal symptoms occur, it is necessary to re-start with the previous dosing regimen until the patient stabilizes and then begin to reduce of daily doses even more gradual.

Patients treated with daily doses of alprazolam greater than 4 mg have more problems with decreasing doses.
Controlled post-marketing studies have shown that the duration of use (up to 6 months) does not significantly affect the withdrawal symptoms in patients with panic disorder.

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